解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Diabetic hypoglycemia produces cognitive-motor slowing, which is assumed to increase risk of automobile crashes. This study investigated driving decrements during and after hypoglycemia, and the patients' awareness of driving decrements. We used a randomized, single-blind, crossover design and conducted the study at t...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diab.42.2.239
更新日期:1993-02-01 00:00:00
abstract::In diabetic subjects, polyol pathway activity might inhibit neutrophil function and cause nerve damage. The effects of ponalrestat, an aldose reductase inhibitor, were assessed on neutrophil intracellular killing of Escherichia coli and on autonomic function in diabetic subjects in a randomized double-blind, placebo-c...
journal_title:Diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2337/diab.42.2.336
更新日期:1993-02-01 00:00:00
abstract::The monoclonal antibodies 2H4 (anti-CD45RA) and UCHL1 (anti-CD45RO) were used to subdivide the CD4 and CD8 T-cell subsets into naive and memory cells. The peripheral blood lymphocytes of 34 patients with recent-onset IDDM, 21 patients with long-standing IDDM, and healthy control subjects of similar age and sex were an...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.42.1.127
更新日期:1993-01-01 00:00:00
abstract::A 5-day culture of adult rat islets with human recombinant IL-1 beta (3 U/ml) resulted in the death of most alpha-cells and 50% of beta-cells. The IL-1--exposed islet tissue contained--in addition to poorly granulated beta-cells--patches of outgrowing monolayers and dispersed activated macrophages. In purified alpha- ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.42.1.56
更新日期:1993-01-01 00:00:00
abstract::Expression of GLUTs in rat peripheral nerve was first studied at the mRNA level with Northern transfer analysis with cDNAs specific for GLUT1, GLUT2, GLUT3, and GLUT4. GLUT1 mRNA was the only GLUT mRNA detectable in rat sciatic nerve. In situ hybridization localized this mRNA to the perineurium and to some endo- and e...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.12.1587
更新日期:1992-12-01 00:00:00
abstract::The effects of elevated EPI and CORT levels on KG, SI, and SG were studied in dogs with alloxan-induced diabetes. Conscious dogs received SAL, EPI 20 ng.kg-1.min-1 for 30 min (short EPI) or 72 h (long EPI), or CORT 200 micrograms.kg-1.min-1 for 60 min (short CORT) or 72 h (long CORT) before assessment of glucose metab...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.11.1446
更新日期:1992-11-01 00:00:00
abstract::Prophylactic insulin can prevent diabetes in the BB rat. We evaluated its use to prevent adoptive transfer of diabetes by activated splenocytes. ConA-activated spleen cells from acutely diabetic BB rats were divided into two equal aliquots and injected intravenously in paired diabetes-prone BB rat littermates. At the ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.10.1273
更新日期:1992-10-01 00:00:00
abstract::Glucose, insulin secretion, and insulin secretory pulses were measured by deconvolution of peripheral C-peptide concentrations in 10 IDDM recipients of a combined kidney-pancreas allograft 6 mo post-transplantation and were compared with 10 matched nondiabetic control subjects. Seven of the 10 recipients were restudie...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.10.1346
更新日期:1992-10-01 00:00:00
abstract::In people with diabetes, the concentration of an individual lipoprotein or apolipoprotein can be highly variable and is totally different in the two major forms of the disease. Alterations in the concentrations of major lipids and lipoproteins are well characterized in both IDDM and NIDDM. In general, the lipoprotein ...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.41.2.s12
更新日期:1992-10-01 00:00:00
abstract::Studies from several laboratories suggest that oxidized LDL may play an important role in atherogenesis. Our group previously showed that treatment of aortic endothelial cells with low levels of MM-LDL caused increased expression of MCP-1, M-CSF, tissue factor, and a monocyte-binding protein. In these studies MM-LDL w...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.41.2.s74
更新日期:1992-10-01 00:00:00
abstract::The association between clinical autonomic dysfunction and myocardial MIBG accumulation was investigated. The study groups comprised 6 male diabetic patients with autonomic neuropathy (ANP+ group), 6 male diabetic patients without autonomic neuropathy (ANP-group), and 6 male nondiabetic control subjects. The mean age ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.9.1069
更新日期:1992-09-01 00:00:00
abstract::This article is divided into two parts. A retrospective overview summarizes some of the work that provided the framework and tools of the more recent studies. The five novel areas of research are related to the indirect effects of insulin. Regulation of plasma glucose is of central importance in health and diabetes. U...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.41.9.1188
更新日期:1992-09-01 00:00:00
abstract::Specific binding of [3H]SCH 23390 to dopamine D1 receptors in the striatum and olfactory tubercle in 14-day alloxan-induced diabetic rats was investigated. The Scatchard analysis revealed decreased D1 receptor density in the striatum (Bmax values were 548 +/- 23 fmol/mg protein for the control and 466 +/- 33 fmol/mg f...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.9.1119
更新日期:1992-09-01 00:00:00
abstract::In diabetic patients, elevated plasma levels of t-PA and PAI-1 accompany impaired fibrinolysis. To identify mechanisms for these abnormalities, we examined whether vascular endothelial cells exposed to high glucose upregulate t-PA and PAI-1 production and whether ambient PA activity is decreased concomitantly. In 17 c...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.8.1009
更新日期:1992-08-01 00:00:00
abstract::To develop somatic gene therapy for diabetes, we studied an animal model with proinsulin-producing fibroblasts with an immunological safety system. Cultured mouse fibroblasts of the Ltk- cell line were transfected first with the efficient human proinsulin expression vector pBMG-Neo-Ins. Initially, 2 x 10(6) cells with...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.8.956
更新日期:1992-08-01 00:00:00
abstract::We previously described a prosthetic group methodology for incorporating 18F into peptides and showed that 18F-labeled insulin (18F-insulin) binds to insulin receptors on human cells (IM-9 lymphoblastoid cells) with affinity equal to that of native insulin (1). We now report studies using 18F-insulin with positron emi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.7.855
更新日期:1992-07-01 00:00:00
abstract::Retrospective studies of patients with non-insulin-dependent diabetes mellitus (NIDDM) have suggested that microalbuminuria predicts early all-cause (mainly cardiovascular) mortality independently of arterial blood pressure. These findings have not been confirmed in prospective studies, and it is not known whether the...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.6.736
更新日期:1992-06-01 00:00:00
abstract::Poorly controlled insulin-dependent diabetes mellitus (IDDM) is associated with elevated basal plasma growth hormone (GH), disproportionally low insulin-like growth factor I (IGF-I) levels, and impaired somatic growth. These derangements in the GH-IGF axis imply a state of GH resistance. The mechanism of GH resistance...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.5.605
更新日期:1992-05-01 00:00:00
abstract::Determinants of proliferative diabetic retinopathy (PDR) that occur during the 2nd decade of insulin-dependent diabetes mellitus (IDDM) (early-onset PDR) were investigated in a nested case-control study. From an inception cohort of patients with juvenile-onset IDDM that now has 15-21 yr diabetes duration, the patients...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.4.430
更新日期:1992-04-01 00:00:00
abstract::Three hundred and seventy-seven children and adolescents aged 5-17 yr from the biracial (black-white) community of Bogalusa, Louisiana, were evaluated for Tanner stage of sexual development, plasma glucose, and insulin levels during an oral glucose tolerance test. Children of the two races were of similar age, weight,...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.3.313
更新日期:1992-03-01 00:00:00
abstract::This article presents a model for the HLA effect in insulin-dependent diabetes mellitus (IDDM) that is almost the mirror image of a model suggested by Nepom. In the Nepom model, the products of certain HLA alleles are associated with IDDM because they bind and present a specific peptide or peptides so as to induce an ...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/diab.41.2.123
更新日期:1992-02-01 00:00:00
abstract::We studied the cross-sectional relationship between HbA1c and cardiovascular disease (CVD) in the survivors of the original cohort of the Framingham Heart Study (n = 1045). HbA1c was significantly related to prevalent CVD among women but not men. HbA1c was also related to hypertension and to the ratio of total to high...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.2.202
更新日期:1992-02-01 00:00:00
abstract::Insulin-dependent diabetes mellitus (IDDM) involves the destruction of the insulin-producing cells in the islets of Langerhans. One possible cure is by transplanting the islet cells; however, transplanted islets, even between identical twins, are subject to autoimmune destruction by the disease process, resulting in d...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.1.114
更新日期:1992-01-01 00:00:00
abstract::The IgG from a patient (Italy 2 [I2]) with hypoglycemia, due to autoantibodies to the insulin receptor, was purified on protein A Sepharose into two fractions that were tested in various human tissues and cells. The IgG fraction that bound protein A (absorbed IgG [IgGa]) nearly completely inhibited the binding of 125I...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.41.1.6
更新日期:1992-01-01 00:00:00
abstract::A single administration of complete Freund's adjuvant (CFA), type 1 carrageenan (Car), or silica 7, 2, and 2 days, respectively, before infection with a low dose (1 x 10(2) plaque-forming units/mouse) of encephalomyocarditis D (EMC-D) virus resulted in a significant increase in the incidence of diabetes in SJL/J mice ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.12.1586
更新日期:1991-12-01 00:00:00
abstract::We have suggested that altered maternal metabolism may affect the subsequent anthropometric and neuropsychological development of children who were in utero during disturbances in maternal fuel economy. This study reports the physical growth through 8 yr of age and the neuropsychological development through 4 yr of ag...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.2.s121
更新日期:1991-12-01 00:00:00
abstract::Birth weights of infants of 35 gestational diabetic mothers treated with calorie restriction alone (1200-1800 kcal) were compared with those of infants of 2337 nondiabetic women, including two control groups (A and B) matched for race, body mass index, age, and parity. All women were screened for gestational diabetes ...
journal_title:Diabetes
pub_type: 临床试验,杂志文章
doi:10.2337/diab.40.2.s161
更新日期:1991-12-01 00:00:00
abstract::We explore whether racial differences in a United States population influence disease prevalence and perinatal outcome in gestational diabetes mellitus (GDM). The data presented are based on 3744 consecutive patients who underwent universal screening at 24-28 wk gestation; those with a 1-h plasma glucose greater than ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.2.s25
更新日期:1991-12-01 00:00:00
abstract::Neonatal morbidity was assessed in the offspring of 878 mothers with gestational diabetes mellitus (GDM), 132 mothers with pre-GDM, and 380 control subjects. Compared with the control group, the GDM group had a higher incidence of complications, including macrosomia, hypoglycemia, hyperbilirubinemia, hypocalcemia, pol...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.2.s74
更新日期:1991-12-01 00:00:00
abstract::Streptozocin-induced diabetic (STZ-D) mice have reduced brain concentrations of tryptophan, a precursor substance for 5-hydroxytryptamine, and show lengthened immobility in Porsolt's swim test, a putative animal model of depression. This study investigated whether tryptophan affects behavior in Porsolt's swim test in ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.12.1598
更新日期:1991-12-01 00:00:00
abstract::Rats from four experimental treatment groups, including fed controls, 24- to 30-h fasted, dexamethasone-treated, and intraperitoneal glucose-treated, were used to assess the effects of these treatments on the immunohistochemically detectable islet amyloid polypeptide (IAPP) content in the pancreatic islets. Isolated p...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.12.1701
更新日期:1991-12-01 00:00:00
abstract::The impaired Na(+)-K(+)-ATPase activity in peripheral nerve from diabetic rats is prevented by dietary myo-inositol (MI) supplementation in vivo and corrected by protein kinase C (PKC) agonists in vitro, suggesting that PKC may mediate the effects of nerve MI depletion on Na(+)-K(+)-ATPase activity. However, little is...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.11.1545
更新日期:1991-11-01 00:00:00
abstract::The effects on N-acetylheparosan deacetylase (N-deacetylase) activity exerted by poorly and well-regulated diabetes and variation of genetic background were investigated in insulin-treated streptozocin-induced diabetic rats of two different strains (H and U). N-deacetylase plays a key role in heparan sulfate biosynthe...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.11.1449
更新日期:1991-11-01 00:00:00
abstract::Tissue accumulation of sorbitol secondary to enhanced polyol-pathway activity is believed to play an important role in the development of diabetic complications. We previously demonstrated sorbitol accumulation, due in part to enhanced expression of aldose reductase (AR) in the diabetic kidney. In this study, we quant...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.11.1391
更新日期:1991-11-01 00:00:00
abstract::Although decreased levels of circulating insulinlike growth factor I (IGF-I) and hepatic IGF-I mRNA in diabetic animal models support a role for insulin in IGF-I regulation, it has been difficult to study the effects of insulin in vitro. Few immortal cell lines exhibit hormone-responsive production of IGF-I, and studi...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.11.1525
更新日期:1991-11-01 00:00:00
abstract::Human CD5+ B lymphocytes produce autoantibodies that bind to self- and exogenous antigens. Extremely high percentages of CD5+ B lymphocytes are present in the fetal and newborn periods, whereas they constitute only a minority of B lymphocytes in healthy adults. Increased percentages of circulating CD5+ lymphocytes hav...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.10.1314
更新日期:1991-10-01 00:00:00
abstract::Phorbol esters translocatively activate and subsequently downregulate protein kinase C and insulin-stimulated glucose uptake in rat adipocytes. This study examined the possibility that other translocative activators of protein kinase C in rat adipocytes, e.g., insulin and glucose, provoke similar downregulating effect...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.10.1274
更新日期:1991-10-01 00:00:00
abstract::A simple, direct assay for T-lymphocyte reactivity to islet antigen(s) in human insulin-dependent diabetes mellitus (IDDM) should facilitate preclinical diagnosis and the evaluation of intervention therapy to avert autoimmune-mediated beta-cell destruction. In subjects with preclinical or clinical IDDM, we measured th...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.9.1128
更新日期:1991-09-01 00:00:00
abstract::The possible influence of diabetes on the higher mnestic and cognitive functions has been investigated. The P300 wave latency, an endogenous electrophysiological event, was explored and compared with the multimodal short-latency evoked potential (EP) recordings (visual [VEP], brainstem auditory [BAEP], and median and ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.8.952
更新日期:1991-08-01 00:00:00
abstract::We tested the hypothesis that dysfunction of vascular endothelium, indicated by an increase in plasma level of von Willebrand factor (vWF), is present in patients with insulin-dependent diabetes mellitus (IDDM) who develop diabetic nephropathy (DN). DN was classified as absent (urinary albumin excretion [UAE] rate les...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/diab.40.8.971
更新日期:1991-08-01 00:00:00